Collagen receptor signalling in platelets: extending the role of the ITAM

被引:164
作者
Watson, SP
Gibbins, J
机构
[1] Univ Oxford, Dept Pharmacol, Oxford OX1 3QT, England
[2] Univ Reading, Sch Anim & Microbial Sci, Reading RG6 6AA, Berks, England
来源
IMMUNOLOGY TODAY | 1998年 / 19卷 / 06期
基金
英国惠康基金;
关键词
D O I
10.1016/S0167-5699(98)01267-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent studies have shown that activation of platelets by collagen is mediated through the same pathway as that used by immune receptors, with pivotal roles for an immunoreceptor tyrosine-based activation motif (ITAM) sequence on the Fc receptor gamma-chain and the tyrosine kinase Syk. Here, Steve Watson and Jonathan Gibbins discuss the implication for the physiological and pathological regulation of blood platelets.
引用
收藏
页码:260 / 264
页数:5
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