Paraspeckles

被引：236

作者：

Fox, Archa H. ^{[1
,2
]}

Lamond, Angus I. ^{[3
]}

机构：

[1] Univ Western Australia, Western Australian Inst Med Res, Crawley, WA 6009, Australia

[2] Univ Western Australia, Med Res Ctr, Crawley, WA 6009, Australia

[3] Univ Dundee, Coll Life Sci, Wellcome Trust Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2010年 / 2卷 / 07期

基金：

英国医学研究理事会;

关键词：

MESSENGER-RNA; NONCODING RNAS; CELL-DIFFERENTIATION; NUCLEAR PARASPECKLES; SPLICING FACTOR; 68-KDA SUBUNIT; PROTEIN; EXPRESSION; DOMAIN; PSF;

D O I：

10.1101/cshperspect.a000687

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Paraspeckles are a relatively new class of subnuclear bodies found in the interchromatin space of mammalian cells. They are RNA-protein structures formed by the interaction between a long nonprotein-coding RNA species, NEAT1/Men epsilon/beta, and members of the DBHS (Drosophila Behavior Human Splicing) family of proteins: P54NRB/NONO, PSPC1, and PSF/SFPQ. Paraspeckles are critical to the control of gene expression through the nuclear retention of RNA containing double-stranded RNA regions that have been subject to adenosine-to-inosine editing. Through this mechanism paraspeckles and their components may ultimately have a role in controlling gene expression during many cellular processes including differentiation, viral infection, and stress responses.

引用

页数：14

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