Endocytosis-like protein uptake in the bacterium Gemmata obscuriglobus

被引：171

作者：

Lonhienne, Thierry G. A. ^{[1
,2
]}

Sagulenko, Evgeny ^{[1
]}

Webb, Richard I. ^{[3
]}

Lee, Kuo-Chang ^{[1
]}

Franke, Josef ^{[4
]}

Devos, Damien P. ^{[5
]}

Nouwens, Amanda ^{[1
]}

Carrolla, Bernard J. ^{[1
,2
]}

Fuerst, John A. ^{[1
]}

机构：

[1] Univ Queensland, Sch Chem & Mol Biosci, Ctr Excellence Integrat Legume Res, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Australian Res Council, Ctr Excellence Integrat Legume Res, St Lucia, Qld 4072, Australia

[3] Univ Queensland, Ctr Microscopy & Microanal, St Lucia, Qld 4072, Australia

[4] Rockefeller Univ, New York, NY 10065 USA

[5] European Mol Biol Lab, D-69117 Heidelberg, Germany

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 29期

基金：

澳大利亚研究理事会; 美国国家卫生研究院;

关键词：

eukaryotes; evolution; endocytosis; bacteria; planctomycetes; BUDDING BACTERIA; CELL COMPARTMENTALIZATION; MEDIATED ENDOCYTOSIS; PLANCTOMYCES GROUP; EVOLUTION; ORIGIN; RNA; VERRUCOMICROBIA; MICROORGANISMS; PHYLOGENY;

D O I：

10.1073/pnas.1001085107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Endocytosis is a process by which extracellular material such as macromolecules can be incorporated into cells via a membrane-trafficking system. Although universal among eukaryotes, endocytosis has not been identified in Bacteria or Archaea. However, intracellular membranes are known to compartmentalize cells of bacteria in the phylum Planctomycetes, suggesting the potential for endocytosis and membrane trafficking in members of this phylum. Here we show that cells of the planctomycete Gemmata obscuriglobus have the ability to uptake proteins present in the external milieu in an energy-dependent process analogous to eukaryotic endocytosis, and that internalized proteins are associated with vesicle membranes. Occurrence of such ability in a bacterium is consistent with autogenous evolution of endocytosis and the endomembrane system in an ancestral noneukaryote cell.

引用

页码：12883 / 12888

页数：6

共 38 条

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