A functional magnetic resonance imaging study of the effects of low frequency right prefrontal transcranial magnetic stimulation in depression

被引:70
作者
Fitzgerald, Paul B.
Sritharan, Anusha
Daskalakis, Zafiris J.
de Castella, Anthony R.
Kulkarni, Jayashri
Egan, Gary
机构
[1] Alfred & Monash Univ, Alfred Psychiat Res Ctr, Dept Med Psychol, Melbourne, Vic 3004, Australia
[2] Ctr Addict & Mental Hlth, Clarke Div, Toronto, ON, Canada
[3] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic, Australia
关键词
D O I
10.1097/jcp.0b013e318151521c
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The study aimed to explore the biological effects of low-frequency repetitive transcranial magnetic stimulation (LFR-TMS) treatment applied to the right prefrontal cortex, comparing this with the effects of high-frequency left-sided (HFL-TMS) in patients with treatment-resistant depression. Twenty-six patients with treatment-resistant depression were randomized to receive either daily LFR-TMS or HFL-TMS treatment for 3 weeks and underwent functional magnetic resonance imaging during a planning task before and after treatment. Patients responded clinically to both forms of treatment with no difference in the degree of response (F-1,F-24 = 0.65; P > 0.05). Low-frequency repetitive transcranial magnetic stimulation resulted in no overall change in task-related activation. However, responders to LFR-TMS demonstrated a bilateral decrease in activity in middle frontal gyrus. In contrast, HFL-TMS produced an increase in activation in left precuneus with responders showing increased activation in several additional regions. Response to LFR-TMS is associated with a bilateral reduction in frontal activation that does not seem to be a nonspecific effect of treatment and differs from the response to HFL-TMS.
引用
收藏
页码:488 / 492
页数:5
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