Objective Assessment of Olfactory Function Using Functional Magnetic Resonance Imaging (fMRI)

被引：15

作者：

Borromeo, Susana ^{[1
]}

Hernandez-Tamames, J. A. ^{[1
]}

Luna, Guillermo ^{[1
]}

Machado, Felipe ^{[1
]}

Malpica, Norberto ^{[1
]}

Toledano, Adolfo ^{[2
]}

机构：

[1] Rey Juan Carlos Univ, Dept Elect Technol, Mostoles 28933, Spain

[2] Fdn Hosp Alcorcon, Serv Otorrinol, Alcorcon 28922, Spain

来源：

IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT | 2010年 / 59卷 / 10期

关键词：

Automated control; component; functional magnetic resonance imaging (fMRI); neuroimaging instrumentation; olfactometer; synchronization; PARKINSONS-DISEASE; STIMULATION; DYSFUNCTION; VALIDATION; POTENTIALS; DEMENTIA;

D O I：

10.1109/TIM.2010.2057531

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

080906 [电磁信息功能材料与结构]; 082806 [农业信息与电气工程];

摘要：

Impairment of the olfactory sensibility can be an indicator of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. The problem lies in obtaining an objective quantitative analysis of olfactory response. For this task, we will use functional magnetic resonance imaging (fMRI) and a device that will provide a selective and controlled stimulation of the olfactory system. The novel issues of our design are synchronization between the acquisition and the olfactory task, and automated control of experimental parameters, odorants sequences, and frequency. We present a review of the basic fMRI experimental design of event-related stimulus paradigms versus block design experiments, and their use in olfactory experiments. Finally, we present the preliminary results obtained on a real 3-T magnetic resonance imaging (MRI) scanner.

引用

页码：2602 / 2608

页数：7

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