Sex differences in the control of sex-hormone-building globulin in the elderly: role of insulin-like growth factor-I and insulin

被引:24
作者
Lecomte, P
Lecureuil, N
Lecureuil, M
Lemonnier, Y
Mariotte, N
Valat, C
Garrigue, MA
机构
[1] UFR Pharm, Biomath, F-37200 Tours, France
[2] CHU Tours, F-37044 Tours, France
关键词
D O I
10.1530/eje.0.1390178
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: Serum levels of sex-hormone-binding globulin (SHBG) have been reported in the literature to increase with age in both sexes. We have investigated the variations in levels of androgens, insulin and IGF-I with age and have evaluated their putative roles to obtain a better understanding of the increase in SHBG. Design: Cross-sectional pilot study of blood samples in healthy elderly subjects aged 50 to 90 years. Patients and Methods: Forty-four postmenopausal women and 40 men were classified into three age groups. Subjects who were obese, undernourished or smokers and postmenopausal women receiving hormone replacement therapy were excluded from the study Body mass index and waist/hip ratio were evaluated in each subject. Fasting levels of blood glucose, insulin, triglycerides, cholesterol, SHBG, testosterone, dehydroepiandrosterone sulfate (DHEAS) and IGF-I were measured. Free testosterone and glucose/insulin ratio were calculated. Results: The results are based on variance analysis of the mean of each parameter in the three age groups. Multiple regression analysis was performed to define the role of age, insulin and IGF-I in the increase in SHBG. The increase in SHBG with age in older men was significant but that in postmenopausal women was not. Decreasing DHEAS with age was confirmed. No significant variations in glucose and insulin were observed with age in our selected population. A positive correlation was observed between insulin and triglycerides in elderly men and women, IGF-I decreased significant with age in both sexes. Insulin was the main factor explaining SHBG increase with age in women. In men, both age and IGF-I contributed to the SHBG increase. Conclusions: The factors regulating the increase in SHBG with age appear to be different in the two sexes. Insulin plays a major role in women, whereas a decrease in IGF-I is the predominant regulating factor in men. These results should be thought of as a working hypothesis rather than a reflection of physiology.
引用
收藏
页码:178 / 183
页数:6
相关论文
共 39 条
[1]   SEX-HORMONE-BINDING GLOBULIN [J].
ANDERSON, DC .
CLINICAL ENDOCRINOLOGY, 1974, 3 (01) :69-96
[2]   Androgens and the menopause; A study of 40-60-year-old women [J].
Bancroft, J ;
Cawood, EHH .
CLINICAL ENDOCRINOLOGY, 1996, 45 (05) :577-587
[3]   INSULIN-LIKE GROWTH FACTOR-I BINDING IN HEPATOCYTES FROM HUMAN-LIVER, HUMAN HEPATOMA, AND NORMAL, REGENERATING, AND FETAL-RAT LIVER [J].
CARO, JF ;
POULOS, J ;
ITTOOP, O ;
PORIES, WJ ;
FLICKINGER, EG ;
SINHA, MK .
JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (04) :976-981
[4]   THE RELATIONSHIP BETWEEN INSULIN-LIKE GROWTH FACTOR-I, ADIPOSITY, AND AGING [J].
COPELAND, KC ;
COLLETTI, RB ;
DEVLIN, JT ;
MCAULIFFE, TL .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1990, 39 (06) :584-587
[5]   HUMAN GROWTH-HORMONE AND HUMAN AGING [J].
CORPAS, E ;
HARMAN, SM ;
BLACKMAN, MR .
ENDOCRINE REVIEWS, 1993, 14 (01) :20-39
[6]   DIFFERENTIAL-EFFECTS OF INSULIN AND INSULIN-LIKE GROWTH-FACTOR-I ON THE PRODUCTION OF PLASMA STEROID-BINDING GLOBULINS BY HUMAN HEPATOBLASTOMA-DERIVED (HEP G2) CELLS [J].
CRAVE, JC ;
LEJEUNE, H ;
BREBANT, C ;
BARET, C ;
PUGEAT, M .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1995, 80 (04) :1283-1289
[7]   HORMONAL CHANGES AND SEXUAL FUNCTION IN AGING MEN [J].
DAVIDSON, JM ;
CHEN, JJ ;
CRAPO, L ;
GRAY, GD ;
GREENLEAF, WJ ;
CATANIA, JA .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (01) :71-77
[8]   GLUCOSE-INTOLERANCE AND AGING [J].
DEFRONZO, RA .
DIABETES CARE, 1981, 4 (04) :493-501
[9]   Serum levels of insulin-like growth factor I and insulin-like growth factor-binding protein 1 correlate with serum free testosterone and sex hormone binding globulin levels in healthy young and middle-aged men [J].
Erfurth, EMT ;
Hagmar, LE ;
Saaf, M ;
Hall, K .
CLINICAL ENDOCRINOLOGY, 1996, 44 (06) :659-664
[10]   RELATIONSHIP OF ANDROGENIC ACTIVITY TO BODY-FAT TOPOGRAPHY, FAT-CELL MORPHOLOGY, AND METABOLIC ABERRATIONS IN PREMENOPAUSAL WOMEN [J].
EVANS, DJ ;
HOFFMANN, RG ;
KALKHOFF, RK ;
KISSEBAH, AH .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1983, 57 (02) :304-310