Study of TLR3, TLR4, and TLR9 in prostate carcinomas and their association with biochemical recurrence

被引：112

作者：

Gonzalez-Reyes, Salome ^{[3
]}

Fernandez, Jesus M. ^{[4
]}

Gonzalez, Luis O. ^{[3
]}

Aguirre, Alina ^{[3
]}

Suarez, Aurelio ^{[2
]}

Gonzalez, Jose M. ^{[3
]}

Escaff, Safwan ^{[2
,3
]}

Vizoso, Francisco J. ^{[1
,3
]}

机构：

[1] Hosp Jove, Serv Cirugia Gen, Gijon 33920, Asturias, Spain

[2] Hosp Jove, Serv Urol, Gijon 33920, Asturias, Spain

[3] Hosp Jove, Unidad Invest, Gijon 33920, Asturias, Spain

[4] Hosp Univ Cent Asturias, Serv Urol, Oviedo, Spain

来源：

CANCER IMMUNOLOGY IMMUNOTHERAPY | 2011年 / 60卷 / 02期

关键词：

Prostate carcinoma; Tissue array; Real time PCR; Prognosis; TLR; Tumor invasion; TOLL-LIKE RECEPTORS; CANCER-CELLS; IMMUNE SURVEILLANCE; EPITHELIAL-CELLS; BREAST-CANCER; TUMOR-GROWTH; INFLAMMATION; DISEASE; INFECTION; BACTERIAL;

D O I：

10.1007/s00262-010-0931-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Toll-like receptors (TLRs) have garnered an extraordinary amount of interest in cancer research due to their role in tumor progression. By activating the production of several biological factors, TLRs induce type I interferons and other cytokines, which drive an inflammatory response and activate the adaptive immune system. The aim of this study was to investigate the expression and clinical relevance of TLR3, 4, and 9 in prostate cancer. The expression levels of TLR3, TLR4, and TLR9 were analyzed on tumors from 133 patients with prostate cancer. The analyses were performed by immunohistochemistry on tissue arrays and real time-PCR. Cancerous cells showed high expression levels of TLRs compared with controls. Samples of carcinomas with recurrence exhibited a significant increase in the mRNA levels of TLR3, TLR4, and TLR9. In addition, the tumors that showed high TLR3 or TLR9 expression levels were significantly associated with higher probability of biochemical recurrence. TLR expression is associated with prostate cancer with recurrence and the role of TLR receptors in the biology of malignancy merits study. Therapeutic strategies to boost or block TLRs may be of interest.

引用

页码：217 / 226

页数：10

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