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Stealth polycyanoacrylate nanoparticles as tumor necrosis factor-α carriers:: Pharmacokinetics and anti-tumor effects

被引：31
作者：
Li, YP
Pei, YY
Zhou, ZH
Zhang, XY
Gu, ZH
Ding, J
Zhou, JJ
Gao, XJ
Zhu, JH
机构：
[1] Fudan Univ, Dept Pharmaceut, Sch Pharm, Shanghai 200032, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 200031, Peoples R China
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2001年 / 24卷 / 06期
关键词：
poly(ethylene glycol); poly(alkyl cyanoacrylate); nanoparticle; stealth; poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate); turner necrosis factor-alpha;
D O I：
10.1248/bpb.24.662
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect of recombinant human tumor necrosis factor-a (rHuTNF-alpha) encapsulated in poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles, Our experimental results showed that PEG-PHDCA nanoparticles could extend the half-life of rHuTNF-alpha to 7.42 h and obviously change the protein biodistribution in tissues, and in particular, increase accumulation of rHuTNF-alpha in tumor. Compared with PHDCA nanoparticles and free rHuTNF-alpha PEG-PHDCA nanoparticles loaded with rHuTNF-alpha showed higher antitumor potency at the same dose, which might be related to its higher accumulation in tumor tissues and longer plasma circulation time. Therefore, PEG-PHDCA nanoparticles could be an effective carrier for rHuTNF-alpha.
引用
收藏
页码：662 / 665
页数：4
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