Time-kill study of the activity of telithromycin against macrolide-resistant Streptococcus pneumoniae isolates with 23S rRNA mutations and changes in ribosomal proteins L4 and L22

被引：6

作者：

Reinert, RR ^{[1
]}

Al-Lahham, A ^{[1
]}

机构：

[1] Univ Aachen, Inst Med Microbiol, Natl Reference Ctr Streptococci, D-52057 Aachen, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 07期

关键词：

D O I：

10.1128/AAC.49.7.3011-3013.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

By use of a time-kill methodology, the antipneumococcal activity of telithromycin was determined against macrolide-resistant S. pneumoniae isolates having mutations in the 23S rRNA gene and changes in the ribosomal proteins L4 and L22. Telithromycin had MICs ranging between 0.03 and 0.25 mu g/ml and was bactericidal against four of seven strains after 24 h at two times the MIC.

引用

页码：3011 / 3013

页数：3

共 14 条

[1] In vitro activities of novel 2-fluoro-naphthyridine-containing ketolides [J].

Abbanat, D ;

Webb, G ;

Foleno, B ;

Li, Y ;

Macielag, M ;

Montenegro, D ;

Wira, E ;

Bush, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (01) :309-315

[2]

[Anonymous], 2004, M100S14 NAT COMM CLI

[3] Macrolide resistance among invasive Streptococcus pneumoniae isolates [J].

Hyde, TB ;

Gay, K ;

Stephens, DS ;

Vugia, DJ ;

Pass, M ;

Johnson, S ;

Barrett, NL ;

Schaffner, W ;

Cieslak, PR ;

Maupin, PS ;

Zell, ER ;

Jorgensen, JH ;

Facklam, RR ;

Whitney, CG .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (15) :1857-1862

[4] Emergence of macrolide resistance during treatment of pneumococcal pneumonia [J].

Musher, DM ;

Dowell, ME ;

Shortridge, VD ;

Flamm, RK ;

Jorgensen, JH ;

Le Magueres, P ;

Krause, KL .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (08) :630-631

[5] Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 pneumococci from 10 Central and Eastern European countries [J].

Nagai, K ;

Appelbaum, PC ;

Davies, TA ;

Kelly, LM ;

Hoellman, DB ;

Tambic Andrasevic, A ;

Drukalska, L ;

Hryniewicz, W ;

Jacobs, MR ;

Kolman, J ;

Miciuleviciene, J ;

Pana, M ;

Setchanova, L ;

Thege, MK ;

Hupkova, H ;

Trupl, J ;

Urbaskova, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (02) :371-377

[6] Activity of telithromycin against erythromycin-susceptible and -resistant Streptococcus pneumoniae isolates from adults with invasive infections [J].

Ortega, M ;

Marco, F ;

Almela, M ;

Puig, J ;

Soriano, A ;

Mensa, J .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2004, 24 (06) :616-618

[7] STUDY OF COMPARATIVE ANTIPNEUMOCOCCAL ACTIVITIES OF PENICILLIN-G, RP-59500, ERYTHROMYCIN, SPARFLOXACIN, CIPROFLOXACIN, AND VANCOMYCIN BY USING TIME-KILL METHODOLOGY [J].

PANKUCH, GA ;

JACOBS, MR ;

APPELBAUM, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (09) :2065-2072

[8] MIC and time-kill study of antipneumococcal activities of RPR 106972 (a new oral streptogramin), RP 59500 (quinupristin-dalfopristin), pyostacine (RP 7293), penicillin G, cefotaxime, erythromycin, and clarithromycin against 10 penicillin-susceptible and -resistant pneumococci [J].

Pankuch, GA ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) :2071-2074

[9] Emergence of macrolide and penicillin resistance among invasive pneumococcal isolates in Germany [J].

Reinert, RR ;

Al-Lahham, A ;

Lemperle, M ;

Tenholte, C ;

Briefs, C ;

Haupts, S ;

Gerards, HH ;

Lütticken, R .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2002, 49 (01) :61-68

[10] Clinical efficacy of ketolides in the treatment of respiratory tract infections [J].

Reinert, RR .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 53 (06) :918-927

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