Statins, ventricular arrhythmias and heart rate variability in patients with implantable cardioverter defibrillators and coronary heart disease

被引：15

作者：

Riahi, S

Schmidt, EB

Christensen, JH

Heath, F

Pedersen, AK

Nielsen, JC

Molgaard, H

Toft, E

机构：

[1] Arhus Univ Hosp, Aalborg Hosp, Dept Cardiol, DK-9100 Aalborg, Denmark

[2] Arhus Univ Hosp, Aalborg Hosp, Cardiovasc Res Ctr, Aalborg, Denmark

[3] Arhus Univ Hosp, Aalborg Hosp, Dept Nephrol, Aalborg, Denmark

[4] Aalborg Univ, Dept Hlth Sci & Technol, Ctr Sensory Motor Interact, Aalborg, Denmark

[5] Arhus Univ Hosp, Dept Cardiol, Skejby Hosp, Aarhus, Denmark

来源：

CARDIOLOGY | 2005年 / 104卷 / 04期

关键词：

heart rate variability; implanted cardioverter defibrillator; HMG-CoA reductase inhibitors; coronary heart disease; plasma lipids;

D O I：

10.1159/000088175

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to evaluate whether the incidence of ventricular arrhythmias and heart rate variability were infl uenced by statin treatment and lipid levels in patients treated with an implantable cardioverter defibrillator (ICD). Heart rate variability measurements were performed in 86 patients with coronary heart disease and an ICD implant. The number of events with ventricular fibrillation and ventricular tachycardia were recorded during a 12-month period. This study lends little support for an antiarrhythmic effect of statins or any relation between plasma lipids and lipoproteins and malignant ventricular arrhythmias in patients with an ICD.

引用

收藏

页码：210 / 214

页数：5

相关论文

共 18 条

[1]

Camm AJ, 1996, CIRCULATION, V93, P1043

[2] Intensive versus moderate lipid lowering with statins after acute coronary syndromes [J].

Cannon, CP ;

Braunwald, E ;

McCabe, CH ;

Rader, DJ ;

Rouleau, JL ;

Belder, R ;

Joyal, SV ;

Hill, KA ;

Pfeffer, MA ;

Skene, AM .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (15) :1495-1504

[3] Heart rate variability and plasma lipids in men with and without ischaemic heart disease [J].

Christensen, JH ;

Toft, E ;

Christensen, MS ;

Schmidt, EB .

ATHEROSCLEROSIS, 1999, 145 (01) :181-186

[4]

Collins R, 2003, LANCET, V361, P2005

[5] Lipid lowering drugs and recurrences of life-threatening ventricular arrhythmias in high-risk patients [J].

De Sutter, J ;

Tavernier, R ;

De Buyzere, M ;

Jordaens, L ;

De Backer, G .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (03) :766-772

[6] Effect of preoperative statin therapy and cardiac outcomes after coronary artery bypass grafting [J].

Dotani, MI ;

Elnicki, DM ;

Jain, AC ;

Gibson, CM .

AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (10) :1128-+

[7] Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels - Results of AFCAPS/TexCAPS [J].

Downs, JR ;

Clearfield, M ;

Weis, S ;

Whitney, E ;

Shapiro, DR ;

Beere, PA ;

Langendorfer, A ;

Stein, EA ;

Kruyer, W ;

Gotto, AM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (20) :1615-1622

[8]

FRIEDEWALD WT, 1972, CLIN CHEM, V18, P499

[9] ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices - Summary article - A report of the American College of Cardiology American Heart Association task force on practice guidelines - (ACC/AHA/NASPE Committee to Update the 1998 Pacemaker Guidelines) [J].

Gregoratos, G ;

Abrams, J ;

Epstein, AE ;

Freedman, RA ;

Hayes, DL ;

Hlatky, MA ;

Kerber, RE ;

Naccarelli, GV ;

Schoenfeld, MH ;

Silka, MJ ;

Winters, SL ;

Gibbons, RJ ;

Antman, EM ;

Alpert, JS ;

Gregoratos, G ;

Hiratzka, LF ;

Faxon, DP ;

Jacobs, AK ;

Fuster, V ;

Smith, SC .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2002, 40 (09) :1703-1719

[10] Effect of pravastatin on cardiovascular events in women after myocardial infarction: The Cholesterol and Recurrent Events (CARE) trial [J].

Lewis, SJ ;

Sacks, FM ;

Mitchell, JS ;

East, C ;

Glasser, S ;

Kell, S ;

Letterer, R ;

Limacher, M ;

Moye, LA ;

Rouleau, JL ;

Pfeffer, MA ;

Braunwald, E .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (01) :140-146