Nanoliposome improves inhibitory effects of naringenin on nonalcoholic fatty liver disease in mice

被引：42

作者：

Chen, Cong ^{[1
]}

Jie, Xu ^{[2
,3
]}

Ou, Yangjie ^{[1
]}

Cao, Yini ^{[1
]}

Xu, Lu ^{[1
]}

Wang, Yunxia ^{[1
]}

Qi, Rong ^{[1
]}

机构：

[1] Peking Univ, Hlth Sci Ctr, Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Inst Cardiovasc Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China

[2] Chongqing Univ, Sch Pharmaceut Sci, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China

[3] Chongqing Univ, Innovat Drug Res Ctr, 55 Daxuecheng South Rd, Chongqing 401331, Peoples R China

来源：

NANOMEDICINE | 2017年 / 12卷 / 15期

基金：

中国国家自然科学基金;

关键词：

nanoliposome; naringenin; nonalcoholic fatty liver disease; GRAPEFRUIT FLAVONOID NARINGENIN; G5 PAMAM DENDRIMER; IN-VITRO; CHOLESTEROL CONTENT; OXIDATIVE STRESS; DRUG DEVELOPMENT; ORAL ABSORPTION; CELLULAR UPTAKE; CANCER CELLS; LUNG-CANCER;

D O I：

10.2217/nnm-2017-0119

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 090105 [作物生产系统与生态工程];

摘要：

Aim: To prepare naringenin nanoliposome (NRG-Nanolipo) and investigate its inhibitory effects on nonalcoholic fatty liver disease (NAFLD). Materials & methods: NRG-Nanolipo was prepared by thin-film rehydration method. Its characterizations and effects on NAFLD in mice induced by methionine choline deficient diet were investigated. Results: NRG-Nanolipo had high-drug loading percentage and showed a sustained release profile. The nanoliposome formulation significantly increased oral absorption of naringenin (NRG). NRG-Nanolipo showed comparable inhibitory effects as NRG crude drug at a dose fourfold lower than the crude drug on NAFLD. Conclusion: It is the first study to report the inhibitory effects of NRG on NAFLD, and the NRG-Nanolipo significantly improved oral absorption of NRG, thus improved liver protective effects of NRG on NAFLD.

引用

收藏

页码：1791 / 1800

页数：10

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