Identification and characterization of BTBD1, a novel BTB domain containing gene on human chromosome 15q24

被引：13

作者：

Carim-Todd, L ^{[1
]}

Sumoy, L ^{[1
]}

Andreu, N ^{[1
]}

Estivill, X ^{[1
]}

Escarceller, M ^{[1
]}

机构：

[1] Hosp Duran & Reynals, Inst Recerca Oncol, Med & Mol Genet Ctr, Barcelona 08907, Spain

来源：

GENE | 2001年 / 262卷 / 1-2期

关键词：

BTB (POZ) domain containing 1; EUROIMAGE; 15q24; 19p;

D O I：

10.1016/S0378-1119(00)00513-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Working within the EUROIMAGE full-length cDNA sequencing project we have isolated BTBD1, a novel human gene with a BTB/POZ domain. This motif is found in developmentally regulated zinc finger proteins and in the kelch family of actin-associated proteins, and is thought to mediate protein-protein interactions. The BTBD1 gene encodes a transcript of 3188 nt with an ORF of 482 amino acids and a predicted protein product size of 52.7 kDa. Northern blot analysis revealed an enhanced BTBD1 expression in heart and skeletal muscle. We have identified a paralogous BTBD1 counterpart gene on chromosome 19, BTBD2. BTBD1 was mapped to chromosome 15q24. Conservation of multiple pairs of genes between 15q24 and 19p13.3-p12 suggests their possible common chromosomal origin. We show the existence of the murine BTBD1 and BTBD2 orthologous genes, as well as the partial rat and bovine homologs. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：275 / 281

页数：7

共 16 条

[1] COMPLEMENTARY-DNA SEQUENCING - EXPRESSED SEQUENCE TAGS AND HUMAN GENOME PROJECT [J].

ADAMS, MD ;

KELLEY, JM ;

GOCAYNE, JD ;

DUBNICK, M ;

POLYMEROPOULOS, MH ;

XIAO, H ;

MERRIL, CR ;

WU, A ;

OLDE, B ;

MORENO, RF ;

KERLAVAGE, AR ;

MCCOMBIE, WR ;

VENTER, JC .

SCIENCE, 1991, 252 (5013) :1651-1656

[2] Crystal structure of the BTB domain from PLZF [J].

Ahmad, KF ;

Engel, CK ;

Privé, GG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12123-12128

[3] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[4] THE POZ DOMAIN - A CONSERVED PROTEIN-PROTEIN INTERACTION MOTIF [J].

BARDWELL, VJ ;

TREISMAN, R .

GENES & DEVELOPMENT, 1994, 8 (14) :1664-1677

[5] A physical map of 30,000 human genes [J].

Deloukas, P ;

Schuler, GD ;

Gyapay, G ;

Beasley, EM ;

Soderlund, C ;

Rodriguez-Tomé, P ;

Hui, L ;

Matise, TC ;

McKusick, KB ;

Beckmann, JS ;

Bentolila, S ;

Bihoreau, MT ;

Birren, BB ;

Browne, J ;

Butler, A ;

Castle, AB ;

Chiannilkulchai, N ;

Clee, C ;

Day, PJR ;

Dehejia, A ;

Dibling, T ;

Drouot, N ;

Duprat, S ;

Fizames, C ;

Fox, S ;

Gelling, S ;

Green, L ;

Harrison, P ;

Hocking, R ;

Holloway, E ;

Hunt, S ;

Keil, S ;

Lijnzaad, P ;

Louis-Dit-Sully, C ;

Ma, J ;

Mendis, A ;

Miller, J ;

Morissette, J ;

Muselet, D ;

Nusbaum, HC ;

Peck, A ;

Rozen, S ;

Simon, D ;

Slonim, DK ;

Staples, R ;

Stein, LD ;

Stewart, EA ;

Suchard, MA ;

Thangarajah, T ;

Vega-Czarny, N .

SCIENCE, 1998, 282 (5389) :744-746

[6]

DEWEINDT C, 1995, CELL GROWTH DIFFER, V6, P1495

[7]

Dhordain P, 1995, ONCOGENE, V11, P2689

[8] Evolution of the vertebrate neurotrophin and Trk receptor gene families [J].

Hallböök, F .

CURRENT OPINION IN NEUROBIOLOGY, 1999, 9 (05) :616-621

[9] The IMAGE consortium: An integrated molecular analysis of genomes and their expression [J].

Lennon, G ;

Auffray, C ;

Polymeropoulos, M ;

Soares, MB .

GENOMICS, 1996, 33 (01) :151-152

[10] EVOLUTION OF THE VERTEBRATE GENOME AS REFLECTED IN PARALOGOUS CHROMOSOMAL REGIONS IN MAN AND THE HOUSE MOUSE [J].

LUNDIN, LG .

GENOMICS, 1993, 16 (01) :1-19

← 1 2 →