Cilia and the cell cycle?

被引：183

作者：

Quarmby, LM ^{[1
]}

Parker, JDK ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

JOURNAL OF CELL BIOLOGY | 2005年 / 169卷 / 05期

关键词：

D O I：

10.1083/jcb.200503053

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A recent convergence of data indicating a relationship between cilia and proliferative diseases, such as polycystic kidney disease, has revived the long-standing enigma of the reciprocal regulatory relationship between cilia and the cell cycle. Multiple signaling pathways are localized to cilia in mammalian cells, and some proteins have been shown to act both in the cilium and in cell cycle regulation. Work from the unicellular alga Chlamydomonas is providing novel insights as to how cilia and the cell cycle are coordinately regulated.

引用

页码：707 / 710

页数：4

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