Asparagine surrogates for the assembly of N-linked glycopeptide mimetics by chemoselective ligation

被引：48

作者：

Peluso, S ^{[1
]}

Imperiali, B ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 11期

基金：

美国国家卫生研究院;

关键词：

glycopeptide mimetic; solid-phase synthesis; chemoselective ligation;

D O I：

10.1016/S0040-4039(01)00104-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alanine-beta -hydroxylamine (A betax) and alanine-beta -hydrazide (A betaz) have been developed as asparagine surrogates for the assembly of N-linked glycopeptide mimetics by chemoselective ligation. The utility of these residues is illustrated with the synthesis of the oligosaccharyl transferase substrate mimetics 1 and 2, and conjugation thereof with GlcNAc to obtain the N-glycopeptide mimetics 3 and 4. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2085 / 2087

页数：3

共 18 条

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