Discovery of metaflumizone, a novel semicarbazone insecticide

被引：53

作者：

Takagi, K. ^{[1
]}

Hamaguchi, H. ^{[2
]}

Nishimatsu, T. ^{[2
]}

Konno, T. ^{[2
]}

机构：

[1] Nihon Nohyaku Co Ltd, Ibaraki 3140255, Japan

[2] Nihon Nohyaku Co Ltd, Chuo Ku, Tokyo 1038236, Japan

来源：

VETERINARY PARASITOLOGY | 2007年 / 150卷 / 03期

关键词：

ProMeris((R)); semicarbazone; metaflumizone; pyrazoline;

D O I：

10.1016/j.vetpar.2007.08.031

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Metaflumizone, (EZ)-2'-[2-(4-cyanophenyl)-1-(alpha,alpha,alpha-trifluoro-m-tolyl)ethylidenel-4-(trifluoromethoxy) carbanilohydrazide, was discovered by Nihon Nohyaku in the early 1990s and belongs to the new class of semicarbazone insecticides. It is now being globally co-developed as the animal health product, ProMeris((R)), in cooperation with Fort Dodge Animal Health and as an agricultural and consumer insecticide in cooperation with BASF. Metaflumizone was developed in a synthesis program initiated from a pyrazoline insecticide lead. In this paper, we describe the development, discovery and structure activity relationships for metaflumizone and related compounds. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：177 / 181

页数：5