DNA-Damage Response in Tissue-Specific and Cancer Stem Cells

被引：271

作者：

Blanpain, Cedric ^{[1
]}

Mohrin, Mary ^{[2
]}

Sotiropoulou, Panagiota A. ^{[1
]}

Passegue, Emmanuelle ^{[2
]}

机构：

[1] Univ Libre Bruxelles, IRIBHM, B-1070 Brussels, Belgium

[2] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Med, Div Hematol Oncol, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2011年 / 8卷 / 01期

基金：

欧洲研究理事会;

关键词：

TUMOR-INITIATING CELLS; MEDIATES RADIATION-RESISTANCE; INDUCED APOPTOSIS; PROGENITOR CELLS; SMALL-INTESTINE; BREAST-CANCER; SELF-RENEWAL; MAMMARY-GLAND; GERM-LINE; IONIZING-RADIATION;

D O I：

10.1016/j.stem.2010.12.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Recent studies have shown that tissue-specific stem cells (SCs) found throughout the body respond differentially to DNA damage. In this review, we will discuss how different SC populations sense and functionally respond to DNA damage, identify various common and distinct mechanisms utilized by tissue-specific SCs to address DNA damage, and describe how these mechanisms can impact SC genomic integrity by potentially promoting aging, tissue atrophy, and/or cancer development. Finally, we will discuss how similar mechanisms operate in cancer stem cells (CSCs) and can mediate resistance to chemo- and radiotherapy.

引用

页码：16 / 29

页数：14

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