Sequencing of Hepatitis C Virus for Detection of Resistance to Direct-Acting Antiviral Therapy: A Systematic Review

被引：26

作者：

Bartlett, Sofia R. ^{[1
]}

Grebely, Jason ^{[1
]}

Eltahla, Auda A. ^{[1
,2
]}

Reeves, Jacqueline D. ^{[3
]}

Howe, Anita Y. M. ^{[4
]}

Miller, Veronica ^{[5
]}

Ceccherini-Silberstein, Francesca ^{[6
]}

Bull, Rowena A. ^{[1
,2
]}

Douglas, Mark W. ^{[7
]}

Dore, Gregory J. ^{[1
]}

Harrington, Patrick ^{[8
]}

Lloyd, Andrew R. ^{[1
,2
]}

Jacka, Brendan ^{[1
]}

Matthews, Gail V. ^{[1
]}

Wang, Gary P. ^{[9
]}

Pawlotsky, Jean-Michel ^{[10
,11
]}

Feld, Jordan J. ^{[12
]}

Schinkel, Janke ^{[13
]}

Garcia, Federico ^{[14
]}

Lennerstrand, Johan ^{[15
]}

Applegate, Tanya L. ^{[1
]}

机构：

[1] Univ New South Wales, Kirby Inst, Sydney, NSW 2052, Australia

[2] Univ New South Wales, Fac Med, Sch Med Sci, Sydney, NSW, Australia

[3] Monogram Biosci, Lab Corp Amer Holdings, San Francisco, CA USA

[4] St Pauls Hosp, British Columbia Ctr Excellence HIV AIDS, Vancouver, BC, Canada

[5] Univ Calif Berkeley, Forum Collaborat HIV Res, Washington, DC USA

[6] Univ Roma Tor Vergata, Dept Expt Med & Surg, Rome, Italy

[7] Univ Sydney, Westmead Inst Med Res, Storr Liver Ctr, Sydney, NSW, Australia

[8] US FDA, Ctr Drug Evaluat & Res, Div Antiviral Prod, Silver Spring, MD USA

[9] Univ Florida, Coll Med, Dept Med, Gainesville, FL USA

[10] Univ Paris Est, Hop Henri Mondor, Dept Virol, Natl Reference Ctr Viral Hepatitis B C & D, Creteil, France

[11] Univ Paris Est, Hop Henri Mondor, INSERM, U955, Creteil, France

[12] Univ Toronto, Univ Hlth Network, Toronto Western Hosp, Liver Ctr, Toronto, ON, Canada

[13] Acad Med Ctr, Dept Med Microbiol, Amsterdam, Netherlands

[14] Complejo Hosp Univ Granada, Clin Microbiol Serv, Granada, Spain

[15] Uppsala Univ, Dept Med Sci, Sect Clin Virol, Uppsala, Sweden

来源：

HEPATOLOGY COMMUNICATIONS | 2017年 / 1卷 / 05期

关键词：

COMBINATION THERAPY; GENOTYPE; NS5A; INFECTION; PREVALENCE; ELBASVIR; POLYMORPHISMS; SUBSTITUTIONS; GRAZOPREVIR; DRUGS;

D O I：

10.1002/hep4.1050

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

The significance of the clinical impact of direct-acting antiviral (DAA) resistance-associated substitutions (RASs) in hepatitis C virus (HCV) on treatment failure is unclear. No standardized methods or guidelines for detection of DAA RASs in HCV exist. To facilitate further evaluations of the impact of DAA RASs in HCV, we conducted a systematic review of RAS sequencing protocols, compiled a comprehensive public library of sequencing primers, and provided expert guidance on the most appropriate methods to screen and identify RASs. The development of standardized RAS sequencing protocols is complicated due to a high genetic variability and the need for genotype- and subtype-specific protocols for multiple regions. We have identified several limitations of the available methods and have highlighted areas requiring further research and development. The development, validation, and sharing of standardized methods for all genotypes and subtypes should be a priority.

引用

页码：379 / 390

页数：12

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