Presence of nicotinic acetylcholine receptors in cat carotid body afferent system

被引：61

作者：

Shirahata, M ^{[1
]}

Ishizawa, Y ^{[1
]}

Rudisill, M ^{[1
]}

Schofield, B ^{[1
]}

Fitzgerald, RS ^{[1
]}

机构：

[1] Johns Hopkins Med Inst, Dept Environm Hlth Sci, Baltimore, MD 21205 USA

来源：

BRAIN RESEARCH | 1998年 / 814卷 / 1-2期

关键词：

antibody; alpha; 7; subunit; chemoreceptor; immunocytochemistry; tyrosine hydroxylase;

D O I：

10.1016/S0006-8993(98)01015-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

With immunocytochemical techniques using a monoclonal antibody for alpha 7 subunits of neuronal nicotinic acetylcholine receptors, we have found these subunits to be exclusively expressed in nerve fibers in the carotid body. Double-immunostaining showed that alpha 7 subunit-positive nerve endings enveloped tyrosine hydroxylase-positive glomus cells. Some carotid sinus nerve fibers and tyrosine hydroxylase-positive petrosal ganglion neurons also expressed alpha 7 subunits. These data support a role for acetylcholine in carotid body neurotransmission. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：213 / 217

页数：5

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