New concepts on the immune modulation mediated by mesenchymal stem cells

被引：102

作者：

Bunnell, Bruce A. ^{[1
,2
,3
]}

Betancourt, Aline M. ^{[1
,4
]}

Sullivan, Deborah E. ^{[1
,4
]}

机构：

[1] Tulane Univ, Sch Med, Ctr Stem Cell Res & Regenerat Med, New Orleans, LA 70112 USA

[2] Tulane Univ, Sch Med, Dept Pharmacol, New Orleans, LA 70112 USA

[3] Tulane Natl Primate Res Ctr, Div Gene Therapy, New Orleans, LA 70112 USA

[4] Tulane Univ, Sch Med, Dept Microbiol & Immunol, New Orleans, LA 70112 USA

来源：

STEM CELL RESEARCH & THERAPY | 2010年 / 1卷

基金：

美国国家卫生研究院;

关键词：

TOLL-LIKE RECEPTORS; MARROW STROMAL CELLS; ADULT STEM/PROGENITOR CELLS; INTER-ALPHA-INHIBITOR; IMMUNOSUPPRESSIVE PROPERTIES; IFN-GAMMA; IN-VITRO; T-CELLS; TRANSPLANTATION; MACROPHAGES;

D O I：

10.1186/scrt34

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Mesenchymal stem cells (MSCs) are the nonhematopoietic multipotent progenitor cells found in various adult tissues. They are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive expansion in culture that yields large quantities suitable for therapeutic use. This article reviews the immunomodulatory activities associated with MSCs. Numerous studies have demonstrated that MSCs are potently immunosuppressive in vitro and in vivo. However, this article presents a new paradigm in MSC biology, in which MSCs, at least in vitro, can undergo polarization into either a pro-inflammatory or an immunosuppressive phenotype.

引用

页数：8

共 88 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].