DLC1: a significant GAP in the cancer genome

被引：75

作者：

Lahoz, Aurelia ^{[1
]}

Hall, Alan ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cell Biol Program, New York, NY 10065 USA

来源：

GENES & DEVELOPMENT | 2008年 / 22卷 / 13期

关键词：

DLC1; HCC; RNAi; RhoA; mouse model;

D O I：

10.1101/gad.1691408

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho GTPases are believed to make important contributions to the development and progression of human cancer, but direct evidence in the form of somatic mutations analogous to those affecting Ras has been lacking. A recent study in Genes & Development by Xue and colleagues (pp. 1439-1444) now provides in vivo evidence that DLC1, a negative regulator of Rho, is a tumor suppressor gene deleted almost as frequently as p53 in common cancers such as breast, colon, and lung.

引用

页码：1724 / 1730

页数：7

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