Histone Deacetylase Inhibitors as a Novel Targeted Therapy Against Non-small Cell Lung Cancer: Where Are We Now and What Should We Expect?

被引：51

作者：

Damaskos, Christos ^{[1
,4
]}

Tomos, Ioannis ^{[5
]}

Garmpis, Nikolaos ^{[1
]}

Karakatsani, Anna ^{[5
]}

Dimitroulis, Dimitrios ^{[1
]}

Garmpi, Anna ^{[2
]}

Spartalis, Eleftherios ^{[4
]}

Kampolis, Christos F. ^{[7
]}

Tsagkari, Eleni ^{[6
]}

Loukeri, Angeliki A. ^{[9
]}

Margonis, Georgios-Antonios ^{[10
]}

Spartalis, Michael ^{[11
]}

Andreatos, Nikolaos ^{[10
]}

Schizas, Dimitrios ^{[3
]}

Kokkineli, Stefania ^{[3
]}

Antoniou, Efstathios A. ^{[1
]}

Nonni, Afroditi ^{[8
]}

Tsourouflis, Gerasimos ^{[1
]}

Markatos, Konstantinos ^{[12
]}

Kontzoglou, Konstantinos ^{[1
]}

Kostakis, Alkiviadis ^{[12
]}

Tomos, Periklis ^{[6
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propedeut Surg 2, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Internal Med, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Sch Med, Laiko Gen Hosp, Dept Surg 1, Athens, Greece

[4] Natl & Kapodistrian Univ Athens, Sch Med, NS Christeas Lab Expt Surg & Surg Res, Athens, Greece

[5] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Pulm Med Dept 2, Athens, Greece

[6] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Thorac Surg, Athens, Greece

[7] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pathophysiol, Athens, Greece

[8] Natl & Kapodistrian Univ Athens, Sch Med, Dept Pathol 1, Athens, Greece

[9] Gen Hosp Chest Dis, Sotiria Hosp, Resp Care Unit, Athens, Greece

[10] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD USA

[11] Onassis Cardiac Surg Ctr, Div Cardiol, Athens, Greece

[12] Acad Athens, Biomed Res Fdn IIBEA, Athens, Greece

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 01期

关键词：

Histone; deacetylase; HDAC; inhibitor; non-small cell; lung; cancer; targeted; epigenetics; review; MESSENGER-RNA EXPRESSION; ANTICANCER THERAPY; HDAC INHIBITOR; BREAST-CANCER; NIVOLUMAB; TRICHOSTATIN; DOCETAXEL; APOPTOSIS; STRATEGY; GROWTH;

D O I：

10.21873/anticanres.12189

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Non-small cell lung cancer constitutes the most common type of lung cancer, accounting for 85-90% of lung cancer, and is a leading cause of cancer-related death. Despite the progress during the past years, poor prognosis remains a challenge and requires further research and development of novel antitumor treatment. Recently, the role of histone deacetylases in gene expression has emerged showing their regulation of the acetylation of histone proteins and other non-histone protein targets and their role in chromatin organization, while their inhibitors, the histone deacetylase inhibitors, have been proposed to have a potential therapeutic role in diverse malignancies, including non-small cell lung cancer. This review article focuses on the role of histone deacetylase inhibitors in the treatment of nonsmall cell lung cancer and the major molecular mechanisms underlying their antitumor activity recognized so far.

引用

页码：37 / 43

页数：7

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