An efficient copper-catalyzed coupling of aryl halides with imidazoles

被引：358

作者：

Kiyomori, A ^{[1
]}

Marcoux, JF ^{[1
]}

Buchwald, SL ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

基金：

美国国家卫生研究院; 美国国家科学基金会; 加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0040-4039(99)00291-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)(2). benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 degrees C. Addition of l,l0-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2657 / 2660

页数：4

共 18 条

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