An efficient copper-catalyzed coupling of aryl halides with imidazoles

被引:358
作者
Kiyomori, A [1 ]
Marcoux, JF [1 ]
Buchwald, SL [1 ]
机构
[1] MIT, Dept Chem, Cambridge, MA 02139 USA
基金
美国国家卫生研究院; 美国国家科学基金会; 加拿大自然科学与工程研究理事会;
关键词
D O I
10.1016/S0040-4039(99)00291-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)(2). benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 degrees C. Addition of l,l0-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2657 / 2660
页数:4
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