Human coronavirus NL63, France

被引：186

作者：

Vabret, A

Mourez, T

Dina, J

van der Hoek, L

Gouarin, S

Petitjean, J

Brouard, J

Freymuth, F

机构：

[1] CHU Caen, Lab Human & Mol Virol, F-14033 Caen, France

[2] Univ Amsterdam, NL-1012 WX Amsterdam, Netherlands

来源：

EMERGING INFECTIOUS DISEASES | 2005年 / 11卷 / 08期

关键词：

D O I：

10.3201/eid1108.050110

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France.

引用

页码：1225 / 1229

页数：5

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