Uncatalysed Knoevenagel condensation in aqueous medium at room temperature

被引：211

作者：

Deb, ML ^{[1
]}

Bhuyan, PJ ^{[1
]}

机构：

[1] Reg Res Lab, Div Med Chem, Jorhat 785006, Assam, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 38期

关键词：

Knoevenagel condensation; barbituric acid; Meldrum's acid; malononitrile; aqueous medium; uncatalysed reaction;

D O I：

10.1016/j.tetlet.2005.07.111

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Knoevenagel condensation of various aromatic and heteroaromatic aldehydes with active methylene compounds like malononitrile, ethyl cyanoacetamide, ethyl cyanoacetate, barbituric acids, Meldrum's acid, dimedone and pyrazolone proceeds smoothly with stirring in an aqueous medium. The reactions occur at room temperature giving excellent yields of the products. The work-up procedure is very simple and the products do not require further purification. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6453 / 6456

页数：4

共 37 条

[1] SILICA-GEL FUNCTIONALIZED WITH AMINO-GROUPS AS A NEW CATALYST FOR KNOEVENAGEL CONDENSATION UNDER HETEROGENEOUS CATALYSIS CONDITIONS [J].