Synthesis of imifuramine and its stereoisomers exhibiting histamine H3 agonistic activity

被引：26

作者：

Harusawa, S

Imazu, T

Takashima, S

Araki, L

Ohishi, H

Kurihara, T

Yamamoto, Y

Yamatodani, A

机构：

[1] Osaka Univ, Fac Med, Sch Allied Hlth Sci, Suita, Osaka 5650871, Japan

[2] Osaka Univ Pharmaceut Sci, Takatsuki, Osaka 5691094, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 13期

关键词：

D O I：

10.1016/S0040-4039(99)00202-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The four possible stereoisomers of a novel imidazole C-nucleoside derivative were synthesized by the efficient use of a PhSe group. Among them, (+)-4(5)-[(2R,5R)-5-(aminomethyl)tetrahydrofuran-2-yl]imidazole (imifuramine) was indicated as a novel type of histamine H-3-agonist by a brain microdialysis method. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2561 / 2564

页数：4

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