Associations among Body Mass Index, Insulin Resistance, and Pancreatic β-Cell Function in Korean Patients with New-Onset Type 2 Diabetes

被引：37

作者：

Chung, Jin Ook

Cho, Dong Hyeok

Chung, Dong Jin

Chung, Min Young

机构：

[1] Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School

来源：

KOREAN JOURNAL OF INTERNAL MEDICINE | 2012年 / 27卷 / 01期

关键词：

Body mass index; Diabetes mellitus; Insulin resistance; Secretion; Type; 2;

D O I：

10.3904/kjim.2012.27.1.66

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background/Aims: We investigated the associations among body mass index (BMI), insulin resistance, and beta-cell function in Korean patients newly presenting with type 2 diabetes. Methods: In total, 132 patients with new-onset type 2 diabetes mellitus were investigated. A standard 75-g oral glucose tolerance test was performed, and the indices of insulin secretion and insulin resistance were calculated. Results: A higher BMI was associated with higher homeostasis model assessment values for insulin resistance (HOMA-IR), homeostasis model assessment of beta-cell function (HOMA-beta), and insulinogenic index as well as lower levels of insulin sensitivity index composite (ISIcomp) and disposition index (DI). In multiple regression models, BMI had independent positive associations with HOMA-IR, ISIcomp, and HOMA-beta and inverse associations with the DI. Conclusions: Our results showed that BMI had independent positive associations with indices of insulin resistance and an inverse association with beta-cell function adjusted for insulin resistance in Korean patients newly presenting with type 2 diabetes.

引用

页码：66 / 71

页数：6

共 25 条

[1] Diagnosis and classification of diabetes mellitus [J].

DIABETES CARE, 2008, 31 :S55-S60

[2] DIFFERENT ETIOLOGIES OF TYPE-2 (NON-INSULIN-DEPENDENT) DIABETES-MELLITUS IN OBESE AND NONOBESE SUBJECTS [J].

ARNER, P ;

POLLARE, T ;

LITHELL, H .

DIABETOLOGIA, 1991, 34 (07) :483-487

[3] PHYSIOLOGIC EVALUATION OF FACTORS CONTROLLING GLUCOSE-TOLERANCE IN MAN - MEASUREMENT OF INSULIN SENSITIVITY AND BETA-CELL GLUCOSE SENSITIVITY FROM THE RESPONSE TO INTRAVENOUS GLUCOSE [J].

BERGMAN, RN ;

PHILLIPS, LS ;

COBELLI, C .

JOURNAL OF CLINICAL INVESTIGATION, 1981, 68 (06) :1456-1467

[4] β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes [J].

Butler, AE ;

Janson, J ;

Bonner-Weir, S ;

Ritzel, R ;

Rizza, RA ;

Butler, PC .

DIABETES, 2003, 52 (01) :102-110

[5] IMPACT OF OBESITY ON INSULIN ACTION IN NIDDM [J].

CAMPBELL, PJ ;

CARLSON, MG .

DIABETES, 1993, 42 (03) :405-410

[6] Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea [J].

Chang, SA ;

Kim, HS ;

Yoon, KH ;

Ko, SH ;

Kwon, HS ;

Kim, SR ;

Lee, WC ;

Yoo, SJ ;

Son, HS ;

Cha, BY ;

Lee, KW ;

Son, HY ;

Kang, SK .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (02) :142-146

[7] THE TRIUMVIRATE - BETA-CELL, MUSCLE, LIVER - A COLLUSION RESPONSIBLE FOR NIDDM [J].

DEFRONZO, RA .

DIABETES, 1988, 37 (06) :667-687

[8]

Ferrannini E, 1998, ENDOCR REV, V19, P477, DOI 10.1210/er.19.4.477

[9] A MODIFIED PROTOCOL FOR ESTIMATION OF INSULIN SENSITIVITY WITH THE MINIMAL MODEL OF GLUCOSE KINETICS IN PATIENTS WITH INSULIN-DEPENDENT DIABETES [J].

FINEGOOD, DT ;

HRAMIAK, IM ;

DUPRE, J .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1990, 70 (06) :1538-1549

[10] Analysis of factors influencing pancreatic β-cell function in Japanese patients with type 2 diabetes: Association with body mass index and duration of diabetic exposure [J].

Funakoshi, Shogo ;

Fujimoto, Shimpei ;

Hamasaki, Akihiro ;

Fujiwara, Hideya ;

Fujita, Yoshihito ;

Ikeda, Kaori ;

Hamamoto, Yoshiyuki ;

Hosokawa, Masaya ;

Seino, Yutaka ;

Inagaki, Nobuya .

DIABETES RESEARCH AND CLINICAL PRACTICE, 2008, 82 (03) :353-358

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