SUMO, hypoxia and the regulation of metabolism

被引：17

作者：

Agbor, Terence A.

Taylor, Cormac T. ^{[1
]}

机构：

[1] Natl Univ Ireland Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland

[2] Natl Univ Ireland Univ Coll Dublin, UCD Conway Inst, Dublin 4, Ireland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷

关键词：

cellular metabolism; hypoxia; metabolic stress; post-translational modification; small ubiquitin-related modifier (SUMO); SUMOylation;

D O I：

10.1042/BST0360445

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Post-translational modification is a critical event in the dynamic regulation of protein stability, location, structure, function, activity and interaction with other proteins and as such plays an important role in organism complexity. Over the last 10 years, the extensive and critical role of one such protein modification by SUMO (small ubiquitin-related modifier) has become apparent. The focus of this mini-review will be on recent reports of a possible functional role for the SUMO pathway in the adaptive cellular response to metabolic challenge, such as oxygen deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function.

引用

页码：445 / 448

页数：4

共 23 条

[1]

Sumoylation increases HIF-1 stability and its transcriptional activity [J].