Modulation of glutamate receptor pathways in the search for new neuroprotective agents

被引：15

作者：

Pellicciari, R ^{[1
]}

Costantino, G ^{[1
]}

Marinozzi, M ^{[1
]}

Natalini, B ^{[1
]}

机构：

[1] Univ Perugia, Ist Chim & Tecnol Farm, I-06123 Perugia, Italy

来源：

FARMACO | 1998年 / 53卷 / 04期

关键词：

metabotropic glutamate receptors; free radicals; 1-aminoindan-1,5-dicarboxylic acid (AIDA); 2-(2 '-carboxy-3 '-phenylcyclopropyl)glycine (PCCG) stereoisomers; fullerene; neuroprotective agents;

D O I：

10.1016/S0014-827X(98)00018-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Excessive stimulation of excitatory amino acid (EAA) receptors is responsible for a wide variety of acute and chronic neurological impairments. A separate line of investigation has focused on oxidative stress as one of the main reasons for several of these degenerative disorders. Current evidence has confirmed that activation of both ionotropic and metabotropic glutamate receptors can also result in either neuroprotection or neurodegeneration according to the role played by oxidative stress mechanisms. An outline of this research, together with our recent results aimed at the discovery of new subtype selective modulators of the central nervous system pathways as well as new classes of free radical scavengers, is presented. (C) 1998 Elsevier Science S.A. All rights reserved.

引用

页码：255 / 261

页数：7

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