The role of hypoxia in inflammatory disease

被引：150

作者：

Biddlestone, John ^{[1
,2
]}

Bandarra, Daniel ^{[1
]}

Rocha, Sonia ^{[1
]}

机构：

[1] Univ Dundee, Coll Life Sci, Ctr Gene Regulat & Express, Dundee DD1 5EH, Scotland

[2] NHS Scotland, Plast Surg Training Programme, Edinburgh, Midlothian, Scotland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2015年 / 35卷 / 04期

基金：

英国惠康基金;

关键词：

hypoxia; inflammation; inflammatory bowel disease; rheumatoid arthritis; colorectal cancer; NF-KAPPA-B; INDUCIBLE FACTOR-I; ENDOTHELIAL GROWTH-FACTOR; HIF-DEPENDENT INDUCTION; CELL-CYCLE ARREST; SIGNAL-TRANSDUCTION; COLORECTAL-CANCER; RHEUMATOID-ARTHRITIS; EXPERIMENTAL COLITIS; TRANSCRIPTIONAL REGULATION;

D O I：

10.3892/ijmm.2015.2079

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

Mammals have developed evolutionarily conserved programs of transcriptional response to hypoxia and inflammation. These stimuli commonly occur together in vivo and there is significant crosstalk between the transcription factors that are classically understood to respond to either hypoxia or inflammation. This crosstalk can be used to modulate the overall response to environmental stress. Several common disease processes are characterised by aberrant transcriptional programs in response to environmental stress. In this review, we discuss the current understanding of the role of the hypoxia-responsive (hypoxia-inducible factor) and inflammatory (nuclear factor-kappa B) transcription factor families and their crosstalk in rheumatoid arthritis, inflammatory bowel disease and colorectal cancer, with relevance for future therapies for the management of these conditions.

引用

页码：859 / 869

页数：11

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