Evaluating the vaccine potential of an influenza A viral hemagglutinin and matrix double insertion DNA plasmid

被引：13

作者：

Xie, Hang ^{[1
]}

Liu, Teresa ^{[1
]}

Chen, Hong ^{[1
]}

Huang, Xiaoyuan ^{[1
]}

Ye, Zhiping ^{[1
]}

机构：

[1] Ctr Biol Evaluat & Res, Div Viral Prod, Pediat Lab & Respiratory Virus Dis, Off Vaccines Res & Review,Food & Drug Adm, Bethesda, MD 20892 USA

来源：

VACCINE | 2007年 / 25卷 / 44期

关键词：

DNA vaccine; influenza; T cell;

D O I：

10.1016/j.vaccine.2007.08.052

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A DNA plasmid expressing both the influenza viral matrix protein (M1) and hemagglutinin (HA) (pHA/M1) as a potential vaccine candidate was investigated. Vaccination with pHA/M1 double insertion plasmids not only induced HA-specific protective antibodies, but also elicited HA and M1-specific CD8 T cell responses. Mice immunized with pHA/M1 dual expressing plasmid showed enhanced HA inhibition titer and increased CD69(+) CD8 alpha(+) T cell response compared to groups that received either the vector or a mixture of both pHA and pM1 (pHA + pM1). Furthermore, pHA/M1 immunization resulted in improved protection against both homologous and heterologous challenges. Published by Elsevier Ltd.

引用

页码：7649 / 7655

页数：7

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