Imidazo[1,2-a]pyridines:: A potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation

被引：104

作者：

Anderson, M ^{[1
]}

Beattie, JF ^{[1
]}

Breault, GA ^{[1
]}

Breed, J ^{[1
]}

Byth, KF ^{[1
]}

Culshaw, JD ^{[1
]}

Ellston, RPA ^{[1
]}

Green, S ^{[1
]}

Minshull, CA ^{[1
]}

Norman, RA ^{[1
]}

Pauptit, RA ^{[1
]}

Stanway, J ^{[1
]}

Thomas, AP ^{[1
]}

Jewsbury, PJ ^{[1
]}

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(03)00638-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

High-throughout screening identified the imidazo[1,2-a]pyridine and bisanilinopyrimidine series as inhibitors of the cyclin-dependent kinase CDK4. Comparison of their experimentally-determined binding modes and emerging structure-activity trends led to the development of potent and selective imidazo[1,2-a]pyridine inhibitors for CDK4 and in particular CDK2. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3021 / 3026

页数：6

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