Pneumolysin potentiates production of prostaglandin E2 and leukotriene B4 by human neutrophils

被引：42

作者：

Cockeran, R

Steel, HC

Mitchell, TJ

Feldman, C

Anderson, R

机构：

[1] Univ Pretoria, Inst Pathol, Dept Immunol, MRC,Unit Inflammat & Immun, ZA-0001 Pretoria, South Africa

[2] Johannesburg Hosp, Div Pulmonol, Johannesburg, South Africa

[3] Univ Witwatersrand, Johannesburg, South Africa

[4] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow, Lanark, Scotland

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 05期

关键词：

D O I：

10.1128/IAI.69.5.3494-3496.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E-2 and leukotriene B-4 by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.

引用

页码：3494 / 3496

页数：3

共 10 条

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BAEHNER RL, 1977, BLOOD, V50, P327

[2] Pneumolysin, a protein toxin of Streptococcus pneumoniae, induces nitric oxide production from macrophages [J].