Serial estimation of flow mediated dilatation in women at risk of hypertensive disorders of pregnancy

被引：19

作者：

Kamat, Runa ^{[1
]}

Jain, Vanita ^{[1
]}

Bahl, Ajay ^{[1
]}

机构：

[1] Post Grad Inst Med Educ & Res, Chandigarh, India

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2011年 / 149卷 / 01期

关键词：

Pregnancy; Flow-mediated vasodilatation (FMD); Hypertension; Preeclampsia; NITRIC-OXIDE; BRACHIAL-ARTERY; ENDOTHELIAL DYSFUNCTION; VASODILATION; UTERINE;

D O I：

10.1016/j.ijcard.2009.11.034

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective: To evaluate the flow mediated vasodilatation of brachial artery in women at risk of development of pregnancy induced hypertension. Methods: We enrolled 81 pregnant women at less than 20 weeks of gestation. Flow mediated vasodilatation (FMD) was assessed twice in pregnancy. The FMD at different gestations were compared between subjects who developed hypertension and those who did not. Results: We observed that FMD was significantly lower in those who developed hypertension. The test gave a sensitivity, specificity, positive predictive value and negative predictive value of 88%, 93%, 84% and 94.8% respectively. When the 2nd FMD was compared with the 1st FMD the sensitivity remained the same but a declining trend was observed. Women with FMD 0-1.1-9.10-30 and > 30% were at 100, 62, 16 and 0% risk to develop hypertension. Conclusion: Flow mediated vasodilatation of brachial artery when measured between 18-24 weeks is found to be a sensitive and useful early predictor of pregnancy induced hypertension. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：17 / 22

页数：6

共 29 条

[1]

Colombian study to assess the use of noninvasive determination of endothelium-mediated vasodilatation (CANDEV).: Normal values and factors associated [J].