An efficient synthesis of 3-cyanoquinoline derivatives

被引：37

作者：

Charpentier, P ^{[1
]}

Lobrégat, V ^{[1
]}

Levacher, V ^{[1
]}

Dupas, G ^{[1
]}

Quéguiner, G ^{[1
]}

Bourguignon, J ^{[1
]}

机构：

[1] IRCOF, INSA, CNRS, Lab Chim Organ Fine & Heterocycl, F-76131 Mt St Aignan, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 23期

关键词：

D O I：

10.1016/S0040-4039(98)00677-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short aid efficient method is reported for the preparation of 3-cyanoquinoline derivatives. Reaction of 3,3-dimethoxy-2-formyl-propanenitrile sodium salt 1 with various anilines 2 afforded (E) enamines 3 which were subsequently isomerized into (Z) enamines 4 and cyclized in a one pot procedure to give 3-cyanoquinolines 5 in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4013 / 4016

页数：4

共 15 条

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