Atrial fibrillation induced by simvastatin treatment in a 61-year-old man

被引：8

作者：

Akahane, T

Mizushige, K

Nishio, H

Fukui, H

Kuriyama, S

机构：

[1] Kagawa Med Univ, Dept Internal Med 3, Miki, Kagawa 7610793, Japan

[2] Nara Med Univ, Dept Internal Med 3, Nara, Japan

[3] Kagawa Med Univ, Dept Internal Med 2, Kagawa, Japan

[4] Kongo Harada Hosp, Osaka, Japan

来源：

HEART AND VESSELS | 2003年 / 18卷 / 03期

关键词：

3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor; atrial fibrillation; left atrial loading; ubiquinone;

D O I：

10.1007/s00380-003-0695-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 61-year-old man developed atrial fibrillation 2 weeks after the administration of simvastatin (5 mg once daily) and recovered to sinus rhythm 3 days after withdrawal of the drug. Electrocardiography had not previously revealed an abnormality except for transient atria] fibrillation and left atrial overloading. Although he has not been given any antiarrhythmic agents, sinus rhythm is being continuously maintained. The timing of the transient atrial fibrillation attack was closely related to the administration of simvastatin. An inhibitory effect of myocardial energy metabolism through ubiquinone synthesis may play a role in the development of atrial fibrillation.

引用

页码：157 / 159

页数：3

共 9 条

[1]

APPELKVIST EL, 1993, CLIN INVESTIGATOR, V71, pS97

[2] EFFECT OF A LONG-TERM TREATMENT WITH LOVASTATIN OR FENOFIBRATE ON HEPATIC AND CARDIAC UBIQUINONE LEVELS IN CARDIOMYOPATHIC HAMSTER [J].

BELICHARD, P ;

PRUNEAU, D ;

ZHIRI, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1993, 1169 (01) :98-102

[3]

BIZZARO N, 1992, CLIN CHEM, V38, P1504

[4] LONG-TERM SAFETY AND EFFICACY PROFILE OF SIMVASTATIN [J].

BOCCUZZI, SJ ;

BOCANEGRA, TS ;

WALKER, JF ;

SHAPIRO, DR ;

KEEGAN, ME .

AMERICAN JOURNAL OF CARDIOLOGY, 1991, 68 (11) :1127-1131

[5] LOVASTATIN DECREASES COENZYME-Q LEVELS IN HUMANS [J].

FOLKERS, K ;

LANGSJOEN, P ;

WILLIS, R ;

RICHARDSON, P ;

XIA, LJ ;

YE, CQ ;

TAMAGAWA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8931-8934

[6] LONG-TERM EFFICACY AND SAFETY OF SIMVASTATIN ALONE AND IN COMBINATION THERAPY IN TREATMENT OF HYPERCHOLESTEROLEMIA [J].

MOLGAARD, J ;

LUNDH, BL ;

VONSCHENCK, H ;

OLSSON, AG .

ATHEROSCLEROSIS, 1991, 91 :S21-S28

[7] SIMVASTATIN IN SEVERE PRIMARY HYPERCHOLESTEROLEMIA - EFFICACY, SAFETY, AND TOLERABILITY IN 595 PATIENTS OVER 18 WEEKS [J].

SIMONS, LA ;

ABRAHAM, R ;

BEILIN, L ;

MASAREI, J ;

BENG, C ;

PANNALL, P ;

CAIN, H ;

BRADFIELD, R ;

CALVERT, GD ;

CORNISH, G ;

ENGLAND, J ;

CRAIG, IH ;

HELLER, RF ;

SMITH, AJ ;

HUNT, D ;

JANUS, ED ;

BEST, JD ;

LLOYD, B ;

HUNG, J ;

NEWNHAM, H ;

BARTER, P ;

SIMONS, LA ;

SULLIVAN, D ;

THOMAS, DW ;

TALLIS, G ;

WAHLQVIST, M ;

WILCKEN, DE ;

TURNER, G ;

WILMSHURST, E ;

CLIFTONBLIGH, P ;

WOODHOUSE, S ;

LEPRE, F .

CLINICAL CARDIOLOGY, 1993, 16 (04) :317-322

[8]

STALENHOEF AF, 1989, AM J MED, V87, P39

[9]

WALKER JF, 1989, AM J MED S4A, V87, P44

← 1 →