Effect of a new immunosuppressive agent, FTY720, on survival of islet allografts

被引：18

作者：

Yamasaki, T ^{[1
]}

Inoue, K ^{[1
]}

Hayashi, H ^{[1
]}

Gu, YJ ^{[1
]}

Setoyama, H ^{[1
]}

Ida, J ^{[1
]}

Cui, WX ^{[1
]}

Kawakami, Y ^{[1
]}

Kogire, M ^{[1
]}

Imamura, M ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med Sci, Dept Surg & Surg Basic Sci, Sakyo Ku, Kyoto 6068397, Japan

来源：

CELL TRANSPLANTATION | 1998年 / 7卷 / 04期

基金：

日本学术振兴会;

关键词：

FTY720; immunosuppressant; islet transplantation; T cell;

D O I：

10.1016/S0963-6897(98)00021-9

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

A newly developed immunosuppressant, FTY720, has a unique mechanism that is quite different from those of conventional immunosuppressants, and is presumed to be mediated through decreases in the number of peripheral lymphocytes, especially helper T cells. This study was performed to ascertain whether this innovative drug could prolong islet allograft survival. The donors were inbred Lewis rats and the recipients were ACI rats rendered hyperglycemic with intravenous streptozotocin. In the study group, FTY720 dissolved in distilled water was orally administered at a dose of 5 mg/kg to the recipient ACI rats 1 day before and on the day of grafting. In the control group, only distilled water was orally administered to the recipient ACI rats on the day before and the day of grafting. Two thousand islets were transplanted into the portal vein of the recipient rats in the study and control groups immediately after isolation. The graft survival time in the study group was significantly longer than that in the control group, indicating that FTY720 retains a potent effect on the prolongation of islet allograft survival. FTY720 could become a useful immunosuppressant for future clinical islet allotransplantation. (C) 1998 Elsevier Science Inc.

引用

页码：403 / 406

页数：4

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