Delivery systems for penetration enhancement of peptide and protein drugs: design considerations (Reprinted from Advanced Drug Delivery Reviews, vol 8, pg 115-162, 1992)

被引：90

作者：

Kompella, UB ^{[1
]}

Lee, VHL ^{[1
]}

机构：

[1] Univ So Calif, John Stauffer Pharmaceut Sci Ctr, Dept Pharmaceut Sci, Sch Pharm, Los Angeles, CA 90089 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 46卷 / 1-3期

关键词：

alveolar deposition; bacterial attachment; gastrointestinal transit; inhaler; lung surfactant; mucoadhesion; mucociliary clearance;

D O I：

10.1016/S0169-409X(00)00137-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This paper discusses the challenges to be met in designing delivery systems that maximize the absorption of peptide and protein drugs from the gastrointestinal and respiratory tracts. The ideal delivery system for either route of administration is one that will release its contents only at a favorable region of absorption, where the delivery system attaches by virtue of specific interaction with surface determinants unique to that region and where the delivery system travels at a rate independent of the transitory constraints inherent of the route of administration. Such a delivery system, which is as yet unavailable, will benefit not only peptide and protein drugs, but other poorly absorbed drugs. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：211 / 245

页数：35

共 275 条

[1] PULMONARY DELIVERY OF PEPTIDE DRUGS - EFFECT OF PARTICLE-SIZE ON BIOAVAILABILITY OF LEUPROLIDE ACETATE IN HEALTHY MALE-VOLUNTEERS [J].