Production of superoxide and nitric oxide by alveolar macrophages in the bleomycin-induced interstitial pneumonia mice model

被引：23

作者：

Yamazaki, C ^{[1
]}

Hoshino, J ^{[1
]}

Sekiguchi, T ^{[1
]}

Hori, Y ^{[1
]}

Miyauchi, S ^{[1
]}

Mizuno, S ^{[1
]}

Horie, K ^{[1
]}

机构：

[1] Seikagaku Corp, Tokyo Res Inst, Tokyo 2070021, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1998年 / 78卷 / 01期

关键词：

superoxide; nitric oxide; fibrosis;

D O I：

10.1254/jjp.78.69

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

To elucidate the potential role of superoxide (O-2(-)) and nitric oxide (NO) in the pathogenesis of interstitial pneumonia, the quantity of O-2(-) and NO produced by the alveolar macrophages (AM) were determined in the bleomycin (BLM)-induced interstitial pneumonia mouse model. The production of O-2(-) and NO increased on days 7, 14 and 21 after BLM injection. Strong expression of peroxynitrite (ONOO-) was seen in AM by using immunostaining for nitrotyrosine. The hydroxyproline contents increased on day 21 after BLM injection. O-2(-) and NO are thought to play an important role in the pathology of fibrosis.

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收藏

页码：69 / 73

页数：5

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