Wound healing: The role of growth factors

被引：199

作者：

Grazul-Bilska, AT

Johnson, ML

Bilski, JJ

Redmer, DA

Reynolds, LP

Abdullah, A

Abdullah, KM

机构：

[1] N Dakota State Univ, Dept Anim & Range Sci, Fargo, ND 58105 USA

[2] N Dakota State Univ, Ctr Cell Biol, Fargo, ND 58105 USA

[3] Plast Surg Inst, Fargo, ND USA

[4] Univ N Dakota, Sch Med, Dept Surg, Grand Forks, ND 58202 USA

来源：

DRUGS OF TODAY | 2003年 / 39卷 / 10期

关键词：

D O I：

10.1358/dot.2003.39.10.799472

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Wound healing is a complex biological process that requires cellular interactions between a variety of cells, including fibroblasts, myofibroblasts, smooth muscle cells, endothelial cells, keratinocytes and immune cells. These interactions are mediated by numerous factors such as growth factors, hormones, blood components and second messengers. Several growth factors that are released at the wound site are presumed to be necessary for wound healing. These include epidermal growth factor (EGF), fibroblast growth factor (FGF), insulin-like growth factor (IGF), keratinocyte growth factor (KGF), platelet-derived growth factor (PDGF), transforming growth factor (TGF) and vascular endothelial growth factor (VEGF). The clinical use of growth factors to stimulate the healing of wounds is currently being investigated. Several growth factors, including PDGF, FGF-2, IGF and KGF, have been used in clinical trials, and PDGF is currently approved for use in human medicine. (C) 2003 Prous Science. All rights reserved.

引用

页码：787 / 800

页数：14

共 157 条

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