Immune complexes as therapy for autoimmunity

被引：42

作者：

Clynes, R ^{[1
]}

机构：

[1] Columbia Univ, Dept Med & Microbiol, New York, NY 10032 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 01期

关键词：

D O I：

10.1172/JCI200523994

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

For several decades, intravenous Ig has been used as treatment for a variety of immune-related diseases, including immune thrombocytopenic purpura (ITP), autoimmune neuropathies, systemic lupus erythematosus, myasthenia gravis, Guillain-Barri syndrome, skin blistering syndromes, and Kawasaki disease. Despite years of use, its mechanism of immunomodulation is still unclear. Recent studies using mouse models of ITP and arthritis, including one reported in this issue of the JCI (see the related article beginning on page 155), now provide some insights into this mechanism and the rationale for the development of Fcgamma receptor-targeted therapeutics.

引用

页码：25 / 27

页数：3

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