In obesity and weight loss, all roads lead to the mighty macrophage

被引：25

作者：

Eagle, Alex Red ^{[1
]}

Chawla, Ajay ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Med, Sch Med, Div Endocrinol Metab & Gerontol, Stanford, CA 94305 USA

[3] Stanford Univ, Grad Program Immunol, Sch Med, Stanford, CA 94305 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2010年 / 120卷 / 10期

关键词：

INSULIN-RESISTANCE; ADIPOSE-TISSUE; INFLAMMATION; ACTIVATION; CELLS; POLARIZATION; EXPRESSION; INFECTION; ADIPOCYTE;

D O I：

10.1172/JCI44721

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Obesity is associated with infiltration of white adipose tissue (WAT) by macrophages, which contributes to the development of insulin resistance. In this issue of the JCI, Kosteli and colleagues demonstrate that weight loss is unexpectedly also associated with rapid, albeit transient, recruitment of macrophages to WAT and that this appears to be related to lipolysis.

引用

页码：3437 / 3440

页数：4

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