3D printing electrospinning fiber-reinforced decellularized extracellular matrix for cartilage regeneration

被引：162

作者：

Chen, Weiming ^{[1
,3
]}

Xu, Yong ^{[2
]}

Li, Yaqiang ^{[4
]}

Jia, Litao ^{[5
]}

Mo, Xiumei ^{[6
]}

Jiang, Gening ^{[2
]}

Zhou, Guangdong ^{[1
,3
,5
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg,Shanghai Key Lab Ti, Shanghai, Peoples R China

[2] Tongji Univ, Shanghai Pulm Hosp, Dept Thorac Surg, Sch Med, Shanghai, Peoples R China

[3] Natl Tissue Engn Ctr China, Shanghai, Peoples R China

[4] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Orthopaed Surg, Sch Med, Shanghai, Peoples R China

[5] Wei Fang Med Coll, Res Inst Plast Surg, Weifang, Shandong, Peoples R China

[6] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai, Peoples R China

来源：

CHEMICAL ENGINEERING JOURNAL | 2020年 / 382卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

3D printing; Cartilage decellularized matrix; Electrospinning fiber; 3D scaffold; Tissue engineering; ACELLULAR DERMAL MATRIX; CHONDROGENIC DIFFERENTIATION; TISSUE; SCAFFOLD; BIOINK; BONE; HYDROGEL; COLLAGEN; REPAIR;

D O I：

10.1016/j.cej.2019.122986

中图分类号：

X [环境科学、安全科学];

学科分类号：

083001 [环境科学];

摘要：

Cartilage decellularized matrix (CDM) is considered a promising biomaterial for fabricating cartilage tissue engineering scaffolds. An ideal CDM-based scaffold should possess customizable 3D shape for complex tissue regeneration and proper pore size for cell infiltration, as well as provide mechanical support for cell growth. 3D printing is an efficiently technique for preparing customizable 3D scaffolds, however, fabricating CDM-based 3D-printed scaffolds with customizable shapes, proper pore structure and satisfactory mechanical properties remains a challenge. In the current study, to achieve customizable CDM-based 3D scaffolds, CDM was successfully processed into inks suitable for 3D printing. Further, the poor mechanics of CDM-based scaffolds were significantly improved by adding electrospinning fiber into the CDM-based inks for 3D printing. Importantly, the 3D-printed electrospinning fiber-reinforced CDM-based scaffold presented good biocompatibility and can enhance repair articular cartilage defects in rabbits. The current study provides a novel strategy for printing electrospinning fiber-reinforced CDM-based scaffolds for tissue regeneration.

引用

页数：11

共 36 条

[1]

[Anonymous], J MAT CHEM B

[2]

Extracellular matrix scaffolds for cartilage and bone regeneration [J].