ALIX catches HIV

被引：34

作者：

Martin-Serrano, Juan

Marsh, Mark

机构：

[1] Guys Hosp, Univ London Kings Coll, Sch Med, Dept Infect Dis, London SE1 9RT, England

[2] MRC Lab Mol Cell Biol, Cell Biol Unit, London WC1E 6BT, England

[3] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

来源：

CELL HOST & MICROBE | 2007年 / 1卷 / 01期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.chom.2007.02.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

ESCRT and ESCRT-associated proteins are required during the assembly and release of many RNA viruses, including HIV. Two new papers provide structures for the ESCRT-associated protein ALIX/ AIP1 and demonstrate how this protein interacts with HIV Gag. One of these studies provides the clearest evidence to date that ESCRT-III mediates key events in virus release and indicates that there are cellular proteins involved in this process still to be discovered.

引用

收藏

页码：5 / 7

页数：3

相关论文

共 11 条

[1] Structural and biochemical studies of ALIX/AIP1 and its role in retrovirus budding [J].

Fisher, Robert D. ;

Chung, Hyo-Young ;

Zhai, Qianting ;

Robinson, Howard ;

Sundquist, Wesley I. ;

Hill, Christopher P. .

CELL, 2007, 128 (05) :841-852

[2] The ESCRT complexes: Structure and mechanism of a membrane-trafficking network [J].

Hurley, James H. ;

Emr, Scott D. .

ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2006, 35 :277-298

[3] Structural basis for endosomal targeting by the Bro1 domain [J].

Kim, JW ;

Sitaraman, S ;

Hierro, A ;

Beach, BM ;

Odorizzi, G ;

Hurley, JH .

DEVELOPMENTAL CELL, 2005, 8 (06) :937-947

[4] Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release [J].

Langelier, Charles ;

von Schwedler, Uta K. ;

Fisher, Robert D. ;

De Domenico, Ivana ;

White, Paul L. ;

Hill, Christopher P. ;

Kaplan, Jerry ;

Ward, Diane ;

Sundquist, Wesley I. .

JOURNAL OF VIROLOGY, 2006, 80 (19) :9465-9480

[5]

LEE S, 2007, NAT STRUCT MOL BIOL

[6] Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins [J].

Martin-Serrano, J ;

Yaravoy, A ;

Perez-Caballero, D ;

Bieniasz, PD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12414-12419

[7] Role of LBPA and Alix in multivesicular liposome formation and endosome organization [J].

Matsuo, H ;

Chevallier, J ;

Mayran, N ;

Le Blanc, I ;

Ferguson, C ;

Fauré, J ;

Blanc, NS ;

Matile, S ;

Dubochet, J ;

Sadoul, R ;

Parton, RG ;

Vilbois, F ;

Gruenberg, J .

SCIENCE, 2004, 303 (5657) :531-534

[8] Retrovirus budding [J].

Morita, E ;

Sundquist, WI .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2004, 20 :395-425

[9] The multiple personalities of Alix [J].

Odorizzi, Greg .

JOURNAL OF CELL SCIENCE, 2006, 119 (15) :3025-3032

[10] AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding [J].

Strack, B ;

Calistri, A ;

Craig, S ;

Popova, E ;

Göttlinger, HG .

CELL, 2003, 114 (06) :689-699