Multigenic control of Listeria monocytogenes susceptibility in mice

被引:63
作者
Boyartchuk, VL
Broman, KW
Mosher, RE
D'Orazio, SEF
Starnbach, MN
Dietrich, W [1 ]
机构
[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Dept Microbiol & Mol Genet, Boston, MA 02115 USA
[3] Johns Hopkins Univ, Dept Biostat, Baltimore, MD 21205 USA
[4] Faulkner Hosp, Dept Pathol, Jamaica Plain, MA USA
关键词
D O I
10.1038/85812
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
We have used a novel quantitative trait locus model to study the genetics of survival of F2 progeny of susceptible BALB/cByJ and resistant C57BL/6ByJ mice that have been infected with Listeria monocytogenes. This allowed us to map modifiers of L. monocytogenes susceptibility to chromosomes 5 and 13.
引用
收藏
页码:259 / 260
页数:2
相关论文
共 13 条
[1]   Genetic epidemiology of infectious diseases in humans: Design of population-based studies [J].
Abel, L ;
Dessein, AJ .
EMERGING INFECTIOUS DISEASES, 1998, 4 (04) :593-603
[2]  
[Anonymous], 1998, Genetics and Analysis of Quantitative Traits (Sinauer)
[3]   RESISTANCE AND SUSCEPTIBILITY OF MICE TO BACTERIAL-INFECTION - GENETICS OF LISTERIOSIS [J].
CHEERS, C ;
MCKENZIE, IFC .
INFECTION AND IMMUNITY, 1978, 19 (03) :755-762
[4]   Using mouse genetics to understand infectious disease pathogenesis [J].
Dietrich, WF .
GENOME RESEARCH, 2001, 11 (03) :325-331
[5]   A comprehensive genetic map of the mouse genome [J].
Dietrich, WF ;
Miller, J ;
Steen, R ;
Merchant, MA ;
DamronBoles, D ;
Husain, Z ;
Dredge, R ;
Daly, MJ ;
Ingalls, KA ;
OConnor, TJ ;
Evans, CA ;
DeAngelis, MM ;
Levinson, DM ;
Kruglyak, L ;
Goodman, N ;
Copeland, NG ;
Jenkins, NA ;
Hawkins, TL ;
Stein, L ;
Page, DC ;
Lander, ES .
NATURE, 1996, 380 (6570) :149-152
[6]  
GERVAIS F, 1984, J IMMUNOL, V132, P2078
[7]  
KRUGLYAK L, 1995, GENETICS, V139, P1421
[8]  
LANDER ES, 1989, GENETICS, V121, P185
[9]   Listeriosis [J].
Lorber, B .
CLINICAL INFECTIOUS DISEASES, 1997, 24 (01) :1-11
[10]  
MANDEL TE, 1980, INFECT IMMUN, V30, P851