Zwitterion-Stabilized Silica Nanoparticles: Toward Nonstick Nano

被引：148

作者：

Estephan, Zaki G. ^{[1
]}

Jaber, Jad A. ^{[1
]}

Schlenoff, Joseph B. ^{[1
]}

机构：

[1] Florida State Univ, Dept Chem & Biochem, Tallahassee, FL 32306 USA

来源：

LANGMUIR | 2010年 / 26卷 / 22期

关键词：

PROTEIN ADSORPTION; NONSPECIFIC ADSORPTION; GOLD NANOPARTICLES; URINARY-EXCRETION; SURFACE; BIODISTRIBUTION; LIQUID; BEHAVIOR; DENSITY; SILANE;

D O I：

10.1021/la103095d

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Using a short-chain zwitterionic organosiloxane, silica nanoparticles were stabilized against aggregation by high ionic strength and/or proteins. Turbidimetry and dynamic light scattering showed that "zwitterated" nanoparticles did not exhibit a significant increase in hydrodynamic radius. When challenged with 3 M NaCl or 50% fetal bovine serum, aggregation was inhibited for at least 24 It, longer with mild heat treatment, which produced nanoparticles with zero net surface charge. These findings suggest "zwitteration" of silica-capped nanoparticles provides excellent stability for in vivo circulation diagnostics and therapies.

引用

页码：16884 / 16889

页数：6

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