Occurrence of amyotrophic lateral sclerosis among Gulf War veterans

被引:203
作者
Horner, RD
Kamins, KG
Feussner, JR
Grambow, SC
Hoff-Lindquist, J
Harati, Y
Mitsumoto, H
Pascuzzi, R
Spencer, PS
Tim, R
Howard, D
Smith, TC
Ryan, MAK
Coffman, CJ
Kasarskis, EJ
机构
[1] NINDS, Rockville, MD 20852 USA
[2] NIEHS, Res Triangle Pk, NC 27709 USA
[3] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA
[4] VA Epidemiol Res & Informat Ctr, Durham, NC 27705 USA
[5] VA Ctr Hlth Serv Res Primary Care, Durham, NC 27705 USA
[6] Duke Univ, Med Ctr, Dept Biostat & Bioinformat, Durham, NC 27705 USA
[7] Houston VA Med Ctr, Houston, TX USA
[8] Baylor Coll Med, Houston, TX 77030 USA
[9] Columbia Presbyterian Med Ctr, New York, NY 10032 USA
[10] Indiana Univ, Med Ctr, Indianapolis, IN USA
[11] Oregon Hlth & Sci Univ, Portland, OR USA
[12] Durham VA Med Ctr, Durham, NC 27705 USA
[13] USN, Hlth Res Ctr, San Diego, CA 92152 USA
[14] Lexington VA Med Ctr, Lexington, KY 40511 USA
[15] Univ Kentucky, Lexington, KY 40536 USA
关键词
D O I
10.1212/01.WNL.0000069922.32557.CA
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: In response to Gulf War veterans' concerns of high rates of ALS, this investigation sought to determine if Gulf War veterans have an elevated rate of ALS. Methods: A nationwide epidemiologic case ascertainment study design was used to ascertain all occurrences of ALS for the 10-year period since August 1990 among active duty military and mobilized Reserves, including National Guard, who served during the Gulf War (August 2, 1990, through July 31, 1991). The diagnosis of ALS was confirmed by medical record review. Risk was assessed by the age-adjusted, average, annual 10-year cumulative incidence rate. Results: Among approximately 2.5 million eligible military personnel, 107 confirmed cases of ALS were identified for an overall occurrence of 0.43 per 100,000 persons per year. A significant elevated risk of ALS occurred among all deployed personnel (RR = 1.92; 95% CL = 1.29, 2.84), deployed active duty military (RR = 2.15, 95% CL = 1.38, 3.36), deployed Air Force (RR = 2.68, 95% CL = 1.24, 5.78), and deployed Army (RR = 2;04; 95% CL = 1.10, 3.77) personnel. Elevated, but nonsignificant, risks were observed for deployed Reserves and National Guard (RR = 2.50; 95% CL = 0.88, 7.07), deployed Navy (RR = 1.48, 95% CL = 0.62, 3.57), and deployed Marine Corps (RR = 1.13; 95% CL = 0.27, 4.79) personnel. Overall, the attributable risk associated with deployment was 18% (95% CL = 4.9%, 29.4%). Conclusions: Military personnel who were deployed to the Gulf Region during the Gulf War period experienced a greater post-war risk of ALS than those who were deployed to the Gulf.
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页码:742 / 749
页数:8
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