Rat carnitine palmitoyltransferase Iβ mRNA splicing isoforms

被引：12

作者：

Yu, GS

Lu, YC

Gulick, T

机构：

[1] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02129 USA

[2] Massachusetts Gen Hosp, Med Serv, Boston, MA 02129 USA

[3] Harvard Univ, Sch Med, Dept Med, Boston, MA USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1998年 / 1393卷 / 01期

关键词：

carnitine palmitoyltransferase; fatty acid oxidation; mRNA splicing; mitochondrion;

D O I：

10.1016/S0005-2760(98)00075-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Carnitine palmitoyltransferase I (CPT-I) catalyzes the rate-determining step in mitochondrial fatty acid beta-oxidation. The enzyme has two cognate structural genes (alpha and beta) that are differentially expressed in tissues. We show multiple mature mRNAs in rat heart derived from alternative splicing of CPT-I beta transcripts. Two novel messages are deleted for regions of the previously described mRNA that encode membrane-spanning and regulatory domains, suggesting that the cognate isozymes will exhibit unique kinetic characteristics. (C) 1998 Published by Elsevier Science B.V. All rights reserved.

引用

页码：166 / 172

页数：7

共 29 条

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