Enantiopure β-hydroxysulfoxide derivatives as novel chiral auxiliaries in asymmetric biaryl Suzuki reactions

被引：47

作者：

Broutin, PE ^{[1
]}

Colobert, F ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, CNRS, UMR 7008, Lab Stereochim Associe, F-67087 Strasbourg 2, France

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 18期

关键词：

D O I：

10.1021/ol0351908

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Highly diastereoselective biaryl Suzuki coupling reactions of (1R)-1-(2-iodo or bromophenyl)-2-(R)-(4-tolylsulfinyl)-1-ethanol derivatives with various aryl- or naphthylboronic acids (or esters) were performed with high yields (up to 99%) and an excellent control of the axial chirality (up to 98% de).

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页码：3281 / 3284

页数：4

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