ΔFosB:: a molecular switch underlying long-term neural plasticity

被引：65

作者：

Kelz, MB

Nestler, EJ

机构：

[1] Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA

[2] Univ Penn, Sch Med, Dept Anesthesiol, Philadelphia, PA 19104 USA

来源：

CURRENT OPINION IN NEUROLOGY | 2000年 / 13卷 / 06期

关键词：

D O I：

10.1097/00019052-200012000-00017

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Numerous chronic perturbations have been shown to induce highly stable isoforms of the transcription factor Delta FosB in the brain in a region-specific manner. This review examines the functional consequences of the induction of Delta FosB in particular neuronal populations as well as its possible role in behavioral abnormalities such as drug addiction and movement disorders. Curr Opin Neurol 13:715-720. (C) 2000 Lippincott Williams & Wilkins.

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页码：715 / 720

页数：6

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