Infections and IBD

被引:71
作者
Irving, Peter M. [1 ,2 ]
Gibson, Peter R. [1 ,2 ]
机构
[1] Box Hill Hosp, Dept Gastroenterol & Med, Box Hill, Vic 3128, Australia
[2] Monash Univ, Box Hill, Vic, Australia
来源
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY | 2008年 / 5卷 / 01期
关键词
Crohn's disease; infections; inflammatory bowel disease; therapy; ulcerative colitis;
D O I
10.1038/ncpgasthep1004
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
An interaction between infection and IBD was identified soon after Crohn's disease and ulcerative colitis were first described. Since then it has become apparent that infectious agents are involved with both the etiopathogenesis and clinical course of IBD on several levels. Whilst our understanding of this interplay is incomplete, it is clear that infections can initiate both the onset and relapse of IBD. Furthermore, the disease process itself predisposes patients to certain infections, and many drugs used to treat IBD also increase the risk of infectious complications. Attempts to establish the relative infectious risks associated with the drugs used to treat IBD remain in an early stage; but it seems that the greatest risks relate to the combined use of immunomodulating agents rather than to individual drugs. The risk of infections in patients with IBD might also be exacerbated by underuse of, and perhaps substandard response to, vaccinations. it is axiomatic that physicians treating patients with IBD must be aware of these infectious risks and of strategies to minimize them. Meanwhile, intriguing advances in the use of parasitic agents as a treatment for ulcerative colitis and Crohn's disease have introduced a new angle to the interplay between infections and IBD.
引用
收藏
页码:18 / 27
页数:10
相关论文
共 73 条
[1]   Colonic perforation in unsuspected amebic colitis [J].
Abbas, MA ;
Mulligan, DC ;
Ramzan, NN ;
Blair, JE ;
Smilack, JD ;
Shapiro, MS ;
Lidner, TK ;
Olden, KW .
DIGESTIVE DISEASES AND SCIENCES, 2000, 45 (09) :1836-1841
[2]   Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease [J].
Alberto, Luis ;
Rodriguez, Garcia ;
Ruigomez, Ana ;
Panes, Julian .
GASTROENTEROLOGY, 2006, 130 (06) :1588-1594
[3]   Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis [J].
Arts, J ;
D'Haens, G ;
Zeegers, M ;
Van Assche, G ;
Hiele, M ;
D'Hoore, A ;
Penninckx, F ;
Vermeire, S ;
Rutgeerts, P .
INFLAMMATORY BOWEL DISEASES, 2004, 10 (02) :73-78
[4]   Diagnosis and treatment of urinary tract complications in Crohn's disease: An experience over 15 years [J].
Ben-Ami, H ;
Ginesin, Y ;
Behar, DM ;
Fischer, D ;
Edoute, Y ;
Lavy, A .
CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2002, 16 (04) :225-229
[5]   Anti-rheumatic drug use and risk of serious infections in rheumatoid arthritis [J].
Bernatsky, S. ;
Hudson, M. ;
Suissa, S. .
RHEUMATOLOGY, 2007, 46 (07) :1157-1160
[6]   Evidence of Epstein-Barr virus infection in ulcerative colitis [J].
Bertalot, G ;
Villanacci, V ;
Gramegna, M ;
Orvieto, E ;
Negrini, R ;
Saleri, A ;
Terraroli, C ;
Ravelli, R ;
Cestari, R ;
Viale, G .
DIGESTIVE AND LIVER DISEASE, 2001, 33 (07) :551-558
[7]   Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies - Systematic review and meta-analysis of rare harmful effects in randomized controlled trials [J].
Bongartz, T ;
Sutton, AJ ;
Sweeting, MJ ;
Buchan, I ;
Matteson, EL ;
Montori, V .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (19) :2275-2285
[8]  
Camus P, 2000, EUR RESPIR J, V15, P5, DOI 10.1034/j.1399-3003.2000.15a03.x
[9]   Effectiveness of recommendations to prevent reactivation of latent tuberculosis infection in patients treated with tumor necrosis factor antagonists [J].
Carmona, L ;
Gómez-Reino, JJ ;
Rodríguez-Valverde, V ;
Montero, D ;
Pascual-Gómez, E ;
Mola, EM ;
Carreño, L ;
Figueroa, T .
ARTHRITIS AND RHEUMATISM, 2005, 52 (06) :1766-1772
[10]   The safety profile of infliximab in patients with Crohn's disease: The Mayo Clinic experience in 500 patients [J].
Colombel, JF ;
Loftus, EV ;
Tremaine, WJ ;
Egan, LJ ;
Harmsen, WS ;
Schleck, CD ;
Zinsmeister, AR ;
Sandborn, WJ .
GASTROENTEROLOGY, 2004, 126 (01) :19-31